منابع مشابه
Mitomycin-C Use in Ophthalmology
Mitomycin-C is a chemotherapeutic drug that acts by inhibiting DNA synthesis. Its use and application in ophthalmology has been increasing in recent years because of its mandatory effects on wound healing. Current applications include pterygium surgery, glaucoma surgery, corneal refractive surgery, cictracial eye disease, conjunctivalneoplasia, dacryocystorhinostomy surgeries and allergic eye d...
متن کاملThe Off - label Use of Mitomycin C
By Steven D. Vold, MD Isolated from the fungus Streptomyces caespitosus, mitomycin C (MMC) inhibits DNA synthesis, which prevents cells from dividing and growing.1,2 It is this quality that led the FDA to approve MMC for the treatment of advanced stomach and pancreatic cancer in combination with other chemotherapeutic agents. MMC is also currently widely used in ophthalmology, including glaucom...
متن کامل5.1. Intraoperative use and needling bleb revision with mitomycin C Intraoperative use and needling bleb revision with mitomycin C
MMC when applied topically or injected subconjunctivally, prevents proliferation of fibroblasts within the subconjunctival space and tenon’s capsule. It also has a lethal effect on vascular endothelial cells. A single application of MMC can cause localized, irreversible inhibition of both fibroblasts and vascular endothelial cells. MMC is estimated to be 100 times more potent than 5-FU in fibro...
متن کاملThe use of mitomycin C in caustic esophagitis in rats.
PURPOSE To evaluate the topical effects of mitomycin C (MMC) in rats, with or without esophageal dilation, in different moments after esophageal caustic injury with NaOH10%. METHODS Forty eight Wistar rats were divided into six groups: "GS" infusion of 0.9% saline solution in the esophagus; "CG" infusion of 0.9% saline solution in the esophagus, with temporary ligation of the organ; "NTG" ind...
متن کاملAdjunctive use of mitomycin C on endoscopic lacrimal surgery.
AIMS Endoscopic endonasal dacryocystorhinostomy (DCR) has some advantages over external DCR as a less invasive method with no skin incisions. But the success rate of the operation has not reached the level of external method. In this study, a wound healing inhibitor mitomycin C was used intraoperatively to prevent the closure of the osteum after the operation. METHODS Endoscopic endonasal DCR...
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ژورنال
عنوان ژورنال: IOSR Journal of Pharmacy (IOSRPHR)
سال: 2013
ISSN: 2319-4219,2250-3013
DOI: 10.9790/3013-31301214